Endocrine Abstracts

Introduction: Patients with germline mutations in one of the succinate dehydrogenase (SDH) genes are at substantially increased risk of developing paragangliomas (PGL) and pheochromocytomas (PCC). Mutations in SDHB are the most commonly found gene mutations in PC/PGL and are associated with younger ages at presentation, higher rates of metastases and poorer prognosis. Although familial PGL syndromes were initially thought to predispose only for PCC and PGL, other tumor types s...

Introduction: Although inpatients hyperglycemia is a current uneasiness among the medical community, its prevalence in Portugal in unknown. We aim to identify ‘Stress hyperglycemia’ and ‘New onset diabetes’ cases in inpatients in a district hospital.Methods: We evaluated inpatients from Internal Medicine (IM), General Surgery (GS), Orthopedics and Traumatology (OT) and Stoke Unit (SU) departments, admitted from the emergency departmen...

Introduction: Pancreas transplantation is an established treatment for selected patients with type 1 diabetes mellitus (T1DM) and severe chronic kidney disease (CKD), reducing mortality and morbidity.Methods: We retrospectively reviewed the cases of pancreas transplantation performed at our centre from 1-January-2011 to 30-June-2016.Results: In this period, 53 transplants were performed: 48 simultaneous pancreas-kidney transplants ...

We report the case of a Caucasian woman presenting with a challenging differential diagnosis of ophtalmopathy. The patient was diagnosed with Graves’ disease during postpartum at the age of 28 (TSH<0.001 U/ml; FT3 6.7 ng/dl; FT4 2.2 ng/dl; TSAb 15 U/l). Besides 16 pack-year smoking history, no other previous disease was known. At examination, exophthalmos grade I/III with bilateral lid retraction was evident. Persistency of the disease despite optimal use of medical a...

Objective: The aim of this study was to evaluate the treatment outcomes in patients with autonomous toxic nodule (ATN) that received a radioiodine treatment (RAIT) and to determine the influence of age, gender, nodule size and iodine activity.Methods: We performed a retrospective study of all RAIT done for hyperthyroidism (n=149) in our hospital during 2014 and 2015. Patients with ATN submitted to RAIT were selected to analysis. We studied 58 pa...

Medullary thyroid carcinoma (MTC) is a rare tumor of C cell origin, that may be sporadic or familial. Diagnosis is often delayed and its course variable.Objectives: Evaluation of clinical characteristics and outcome of patients diagnosed with MTC.Methods: Retrospective analysis of clinical records of patients with MTC between 2005 and 2016. We considered undetectable serum calcitonin as criteria of cure.Resul...

Introduction: Signalling lymphocytic activation molecule SLAMF1 (CD150) is a modulatory receptor expressed in most immune cells. Different data indicate that CD150 is involved in T cell cytokine production, NK cell and CD8 T cell mediated cytotoxicity, and T regulatory (Treg) cell activity. Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function CD150 in lymphocytes subpopulations from p...

Introduction: Some authors consider aldosteronism to be a spectrum, ranging from aldosterone-associated (or low-renin) hypertension (AAH) to primary hyperaldosteronism (PHA) due to bilateral adrenal hyperplasia. Thus, blood pressure (BP) response to mineralocorticoid-receptor blockade (MRB) could be similar.Methods: Retrospective analysis of 60 patients. Screening per Endocrine Society guidelines, positive screening: aldosterone (pg/ml) to direct-renin (...

Introduction: Bariatric surgery improves lipid profile. A still unanswered question is whether this improvement is merely weight dependent or also results from factors inherent to specificities of the bariatric procedure itself. We aimed to study lipid profile 1 year after bariatric surgery and compare its changes between the different procedures in patients matched for initial weight and for weight loss.Methods: We retrospectively analysed patients subm...

Introduction: Cardiovascular changes are rare but life-threatening consequences of primary hyperparathyroidism.Case report: A 53-year-old man, with past and family history of peptic ulcer, presenting with coronary heart disease and ischemic and dilated cardiomyopathy, treated with cardiac resynchronization. He was admitted to the emergency room due to sustained monomorphic ventricular tachycardia (MVT). Laboratory tests revealed primary hyperparathyroidi...